Arntl Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comArntl Polyclonal Antibody for Mouse(Mus musculus)

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Arntl (Gene name),

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Protein name ), BMAL1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Arntl(Bmal1);

Protein name:

Aryl hydrocarbon receptor nuclear translocator-like protein 1;

Alternative:

Brain and muscle ARNT-like 1;Arnt3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo (By similarity). Part of a nuclear complex which also includes GNB2L1/RACK1 and PRKCA; GNB2L1 and PRKCA are recruited to the complex in a circadian manner.

Function:

ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

632

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

632:

NDEAAMAVIM | SLLEADAGLG | GPVDFSDLPW | PL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9WTL8

KEGG:

mmu:11865

String:

Q9WTL8

UniGene:

Mm.440371

Pfam:

PF00010

Uniprot:

Q9WTL8

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ELISA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

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E10272h

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96T

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ELISA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

E10272c

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96T

ELISA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

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E10272r

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96T

ELISA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

E10272m

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96T

CLIA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

U10272h

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96T

CLIA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

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U10272c

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Packing:

96T

CLIA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

U10272m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

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U10272r

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96T

Polyclonal Antibody for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

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P10272Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

P10272Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Cat.:

P10272Rb-r

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Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

Protein for Mouse Aryl hydrocarbon receptor nuclear translocator-like protein 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Characterization of three splice variants and genomic organization of the mouse BMAL1 gene."
Yu W. , Ikeda M. , Abe H. , Honma S. , Ebisawa T. , Yamauchi T. , Honma K. , Nomura M.
Biochem. Biophys. Res. Commun.260:760-767(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 5)
tissue: Brain.
2.

"Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock."
Takahata S. , Sogawa K. , Kobayashi A. , Ema M. , Mimura J. , Ozaki N. , Fujii-Kuriyama Y.
Biochem. Biophys. Res. Commun.248:789-794(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
4.

"Role of the CLOCK protein in the mammalian circadian mechanism."
Gekakis N. , Staknis D. , Nguyen H.B. , Davis F.C. , Wilsbacher L.D. , King D.P. , Takahashi J.S. , Weitz C.J.
Science280:1564-1569(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLOCK
5.

"Posttranslational mechanisms regulate the mammalian circadian clock."
Lee C. , Etchegaray J.-P. , Cagampang F.R.A. , Loudon A.S.I. , Reppert S.M.
Cell107:855-867(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CLOCK; PER1; PER2; CRY1; CRY2; CSNK1D AND CSNK1E;PHOSPHORYLATION;SUBCELLULAR LOCATION
6.

"Dec1 and Dec2 are regulators of the mammalian molecular clock."
Honma S. , Kawamoto T. , Takagi Y. , Fujimoto K. , Sato F. , Noshiro M. , Kato Y. , Honma K.I.
Nature419:841-844(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BHLHE40 AND BHLHE41
7.

"BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system."
Kondratov R.V. , Chernov M.V. , Kondratova A.A. , Gorbacheva V.Y. , Gudkov A.V. , Antoch M.P.
Genes Dev.17:1921-1932(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUBCELLULAR LOCATION
8.

"A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
Kawamoto T. , Noshiro M. , Sato F. , Maemura K. , Takeda N. , Nagai R. , Iwata T. , Fujimoto K. , Furukawa M. , Miyazaki K. , Honma S. , Honma K.I. , Kato Y.
Biochem. Biophys. Res. Commun.313:117-124(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Circadian clock control by SUMOylation of BMAL1."
Cardone L. , Hirayama J. , Giordano F. , Tamaru T. , Palvimo J.J. , Sassone-Corsi P.
Science309:1390-1394(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-266;MUTAGENESIS OF LYS-230; LYS-236; LYS-266 AND LYS-279
10.

"Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES."
Kondratov R.V. , Kondratova A.A. , Lee C. , Gorbacheva V.Y. , Chernov M.V. , Antoch M.P.
Cell Cycle5:890-895(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NPAS2
11.

"The polycomb group protein EZH2 is required for mammalian circadian clock function."
Etchegaray J.P. , Yang X. , DeBruyne J.P. , Peters A.H. , Weaver D.R. , Jenuwein T. , Reppert S.M.
J. Biol. Chem.281:21209-21215(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EZH2; CLOCK; PER1; PER2; CRY1 AND CRY2
12.

"BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer."
Kwon I. , Lee J. , Chang S.H. , Jung N.C. , Lee B.J. , Son G.H. , Kim K. , Lee K.H.
Mol. Cell. Biol.26:7318-7330(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL;NUCLEAR EXPORT SIGNAL;INTERACTION WITH CLOCK;MUTAGENESIS OF 38-LYS-ARG-39; LEU-154; LEU-157; LEU-370 AND LEU-374;UBIQUITINATION;PROTEASOMAL DEGRADATION
13.

"Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."
Partch C.L. , Shields K.F. , Thompson C.L. , Selby C.P. , Sancar A.
Proc. Natl. Acad. Sci. U.S.A.103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
14.

"CLOCK-mediated acetylation of BMAL1 controls circadian function."
Hirayama J. , Sahar S. , Grimaldi B. , Tamaru T. , Takamatsu K. , Nakahata Y. , Sassone-Corsi P.
Nature450:1086-1090(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-544
15.

"Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK."
Langmesser S. , Tallone T. , Bordon A. , Rusconi S. , Albrecht U.
BMC Mol. Biol.9:41-41(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1; CRY2 AND PER2
16.

"SIRT1 regulates circadian clock gene expression through PER2 deacetylation."
Asher G. , Gatfield D. , Stratmann M. , Reinke H. , Dibner C. , Kreppel F. , Mostoslavsky R. , Alt F.W. , Schibler U.
Cell134:317-328(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIRT1 AND CLOCK
17.

"The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control."
Nakahata Y. , Kaluzova M. , Grimaldi B. , Sahar S. , Hirayama J. , Chen D. , Guarente L.P. , Sassone-Corsi P.
Cell134:329-340(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-544;DEACETYLATION;INTERACTION WITH SIRT1
18.

"The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice."
Alvarez J.D. , Hansen A. , Ord T. , Bebas P. , Chappell P.E. , Giebultowicz J.M. , Williams C. , Moss S. , Sehgal A.
J. Biol. Rhythms23:26-36(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
19.

"Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators."
Bertolucci C. , Cavallari N. , Colognesi I. , Aguzzi J. , Chen Z. , Caruso P. , Foa A. , Tosini G. , Bernardi F. , Pinotti M.
Mol. Cell. Biol.28:3070-3075(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex."
Lee J. , Lee Y. , Lee M.J. , Park E. , Kang S.H. , Chung C.H. , Lee K.H. , Kim K.
Mol. Cell. Biol.28:6056-6065(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-259;SUBCELLULAR LOCATION;INTERACTION WITH SUMO3;MUTAGENESIS OF LYS-259;UBIQUITINATION;PROTEASOMAL DEGRADATION
21.

"A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation."
Spengler M.L. , Kuropatwinski K.K. , Schumer M. , Antoch M.P.
Cell Cycle8:4138-4146(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B AND CLOCK;PHOSPHORYLATION
22.

"Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications."
Nader N. , Chrousos G.P. , Kino T.
FASEB J.23:1572-1583(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription."
Sasaki M. , Yoshitane H. , Du N.H. , Okano T. , Fukada Y.
J. Biol. Chem.284:25149-25159(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PER2
24.

"Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription."
Yoshitane H. , Takao T. , Satomi Y. , Du N.H. , Okano T. , Fukada Y.
Mol. Cell. Biol.29:3675-3686(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
25.

"CK2alpha phosphorylates BMAL1 to regulate the mammalian clock."
Tamaru T. , Hirayama J. , Isojima Y. , Nagai K. , Norioka S. , Takamatsu K. , Sassone-Corsi P.
Nat. Struct. Mol. Biol.16:446-448(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-97;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-97;INTERACTION WITH CLOCK
26.

"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis."
Ramsey K.M. , Yoshino J. , Brace C.S. , Abrassart D. , Kobayashi Y. , Marcheva B. , Hong H.K. , Chong J.L. , Buhr E.D. , Lee C. , Takahashi J.S. , Imai S. , Bass J.
Science324:651-654(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SIRT1
27.

"Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1."
Nakahata Y. , Sahar S. , Astarita G. , Kaluzova M. , Sassone-Corsi P.
Science324:654-657(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction."
Ozber N. , Baris I. , Tatlici G. , Gur I. , Kilinc S. , Unal E.B. , Kavakli I.H.
BMC Mol. Biol.11:69-69(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CRY2
29.

"Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2."
Shi S. , Hida A. , McGuinness O.P. , Wasserman D.H. , Yamazaki S. , Johnson C.H.
Curr. Biol.20:316-321(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2."
Doi R. , Oishi K. , Ishida N.
J. Biol. Chem.285:22114-22121(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
31.

"The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression."
Ward S.M. , Fernando S.J. , Hou T.Y. , Duffield G.E.
J. Biol. Chem.285:38987-39000(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH ID1; ID2 AND ID3
32.

"Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver."
Guillaumond F. , Grechez-Cassiau A. , Subramaniam M. , Brangolo S. , Peteri-Brunback B. , Staels B. , Fievet C. , Spelsberg T.C. , Delaunay F. , Teboul M.
Mol. Cell. Biol.30:3059-3070(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
33.

"The histone methyltransferase MLL1 permits the oscillation of circadian gene expression."
Katada S. , Sassone-Corsi P.
Nat. Struct. Mol. Biol.17:1414-1421(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KMT2A
34.

"Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes."
Marcheva B. , Ramsey K.M. , Buhr E.D. , Kobayashi Y. , Su H. , Ko C.H. , Ivanova G. , Omura C. , Mo S. , Vitaterna M.H. , Lopez J.P. , Philipson L.H. , Bradfield C.A. , Crosby S.D. , Je Bailey L. , Wang X. , Takahashi J.S. , Bass J.
Nature466:627-631(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
35.

"Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation."
Sahar S. , Zocchi L. , Kinoshita C. , Borrelli E. , Sassone-Corsi P.
PLoS ONE5:E8561-E8561(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-17 AND THR-21;INTERACTION WITH GSK3B
36.

"CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function."
Andrews J.L. , Zhang X. , McCarthy J.J. , McDearmon E.L. , Hornberger T.A. , Russell B. , Campbell K.S. , Arbogast S. , Reid M.B. , Walker J.R. , Hogenesch J.B. , Takahashi J.S. , Esser K.A.
Proc. Natl. Acad. Sci. U.S.A.107:19090-19095(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
37.

"Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock."
Robles M.S. , Boyault C. , Knutti D. , Padmanabhan K. , Weitz C.J.
Science327:463-466(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1 AND PRKCA;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
38.

"Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene."
Xu C.X. , Krager S.L. , Liao D.F. , Tischkau S.A.
Toxicol. Sci.115:98-108(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AHR
39.

"Circadian clock protein BMAL1 regulates cellular senescence in vivo."
Khapre R.V. , Kondratova A.A. , Susova O. , Kondratov R.V.
Cell Cycle10:4162-4169(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
40.

"Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in beta-cells."
Lee J. , Kim M.S. , Li R. , Liu V.Y. , Fu L. , Moore D.D. , Ma K. , Yechoor V.K.
Islets3:381-388(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
41.

"Biochemical analysis of the canonical model for the mammalian circadian clock."
Ye R. , Selby C.P. , Ozturk N. , Annayev Y. , Sancar A.
J. Biol. Chem.286:25891-25902(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLOCK; CRY1 AND PER2
42.

"cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene."
Koyanagi S. , Hamdan A.M. , Horiguchi M. , Kusunose N. , Okamoto A. , Matsunaga N. , Ohdo S.
J. Biol. Chem.286:32416-32423(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
43.

"Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype."
Somanath P.R. , Podrez E.A. , Chen J. , Ma Y. , Marchant K. , Antoch M. , Byzova T.V.
J. Cell. Physiol.226:132-140(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
44.

"Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation."
Shimba S. , Ogawa T. , Hitosugi S. , Ichihashi Y. , Nakadaira Y. , Kobayashi M. , Tezuka M. , Kosuge Y. , Ishige K. , Ito Y. , Komiyama K. , Okamatsu-Ogura Y. , Kimura K. , Saito M.
PLoS ONE6:E25231-E25231(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
45.

"Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock."
DiTacchio L. , Le H.D. , Vollmers C. , Hatori M. , Witcher M. , Secombe J. , Panda S.
Science333:1881-1885(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5A
46.

"The RelB subunit of NFkappaB acts as a negative regulator of circadian gene expression."
Bellet M.M. , Zocchi L. , Sassone-Corsi P.
Cell Cycle11:3304-3311(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RELB
47.

"The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway."
Guo B. , Chatterjee S. , Li L. , Kim J.M. , Lee J. , Yechoor V.K. , Minze L.J. , Hsueh W. , Ma K.
FASEB J.26:3453-3463(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
48.

"Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome."
Stratmann M. , Suter D.M. , Molina N. , Naef F. , Schibler U.
Mol. Cell48:277-287(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
49.

"Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells."
Peruquetti R.L. , de Mateo S. , Sassone-Corsi P.
PLoS ONE7:E42695-E42695(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH DDX4
50.

"PKCgamma participates in food entrainment by regulating BMAL1."
Zhang L. , Abraham D. , Lin S.T. , Oster H. , Eichele G. , Fu Y.H. , Ptacek L.J.
Proc. Natl. Acad. Sci. U.S.A.109:20679-20684(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRKCG;UBIQUITINATION;PROTEASOMAL DEGRADATION
51.

"A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention."
Richards J. , Cheng K.Y. , All S. , Skopis G. , Jeffers L. , Lynch I.J. , Wingo C.S. , Gumz M.L.
Am. J. Physiol.305:F1697-F1704(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PER1;TISSUE SPECIFICITY
52.

"High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice."
Barclay J.L. , Shostak A. , Leliavski A. , Tsang A.H. , Johren O. , Muller-Fielitz H. , Landgraf D. , Naujokat N. , van der Horst G.T. , Oster H.
Am. J. Physiol.304:E1053-E1063(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
53.

"Mechanism of the circadian clock in physiology."
Richards J. , Gumz M.L.
Am. J. Physiol.304:R1053-R1064(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
54.

"The clock gene brain and muscle Arnt-like protein-1 (BMAL1) is involved in hair growth."
Watabe Y. , Tomioka M. , Watabe A. , Aihara M. , Shimba S. , Inoue H.
Arch. Dermatol. Res.305:755-761(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
55.

"The molecular clock regulates circadian transcription of tissue factor gene."
Oishi K. , Koyanagi S. , Ohkura N.
Biochem. Biophys. Res. Commun.431:332-335(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
56.

"O-GlcNAcylation of BMAL1 regulates circadian rhythms in NIH3T3 fibroblasts."
Ma Y.T. , Luo H. , Guan W.J. , Zhang H. , Chen C. , Wang Z. , Li J.D.
Biochem. Biophys. Res. Commun.431:382-387(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;INTERACTION WITH OGT
57.

"Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor."
Yoshii K. , Ishijima S. , Sagami I.
Biochem. Biophys. Res. Commun.437:386-391(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
58.

"O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination."
Li M.D. , Ruan H.B. , Hughes M.E. , Lee J.S. , Singh J.P. , Jones S.P. , Nitabach M.N. , Yang X.
Cell Metab.17:303-310(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;UBIQUITINATION;MUTAGENESIS OF SER-418
59.

"The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit."
Bouchard-Cannon P. , Mendoza-Viveros L. , Yuen A. , Kaern M. , Cheng H.Y.
Cell Rep.5:961-973(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
60.

"Brain and muscle Arnt-like 1 is a key regulator of myogenesis."
Chatterjee S. , Nam D. , Guo B. , Kim J.M. , Winnier G.E. , Lee J. , Berdeaux R. , Yechoor V.K. , Ma K.
J. Cell Sci.126:2213-2224(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
61.

"Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration."
Musiek E.S. , Lim M.M. , Yang G. , Bauer A.Q. , Qi L. , Lee Y. , Roh J.H. , Ortiz-Gonzalez X. , Dearborn J.T. , Culver J.P. , Herzog E.D. , Hogenesch J.B. , Wozniak D.F. , Dikranian K. , Giasson B.I. , Weaver D.R. , Holtzman D.M. , Fitzgerald G.A.
J. Clin. Invest.123:5389-5400(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
62.

"Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells."
Hwang C.K. , Chaurasia S.S. , Jackson C.R. , Chan G.C. , Storm D.R. , Iuvone P.M.
J. Neurosci.33:14989-14997(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
63.

"Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice."
Lee J. , Moulik M. , Fang Z. , Saha P. , Zou F. , Xu Y. , Nelson D.L. , Ma K. , Moore D.D. , Yechoor V.K.
Mol. Cell. Biol.33:2327-2338(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
64.

"Metastasis-associated protein 1 is an integral component of the circadian molecular machinery."
Li D.Q. , Pakala S.B. , Reddy S.D. , Peng S. , Balasenthil S. , Deng C.X. , Lee C.C. , Rea M.A. , Kumar R.
Nat. Commun.4:2545-2545(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1
65.

"Global loss of Bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism."
Kennaway D.J. , Varcoe T.J. , Voultsios A. , Boden M.J.
PLoS ONE8:E65255-E65255(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
66.

"Metabolism and the circadian clock converge."
Eckel-Mahan K. , Sassone-Corsi P.
Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
67.

"Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes."
Nguyen K.D. , Fentress S.J. , Qiu Y. , Yun K. , Cox J.S. , Chawla A.
Science341:1483-1488(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CLOCK; EED; EZH2 AND SUZ12
68.

"BMAL1-dependent regulation of the mTOR signaling pathway delays aging."
Khapre R.V. , Kondratova A.A. , Patel S. , Dubrovsky Y. , Wrobel M. , Antoch M.P. , Kondratov R.V.
Aging (Albany NY)6:48-57(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
69.

"Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice."
Noh J.Y. , Han D.H. , Kim M.H. , Ko I.G. , Kim S.E. , Park N. , Kyoung Choe H. , Kim K.H. , Kim K. , Kim C.J. , Cho S.
Exp. Mol. Med.46:E81-E81(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY
70.

"CLOCK:BMAL1 is a pioneer-like transcription factor."
Menet J.S. , Pescatore S. , Rosbash M.
Genes Dev.28:8-13(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
71.

"CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1."
Zhou B. , Zhang Y. , Zhang F. , Xia Y. , Liu J. , Huang R. , Wang Y. , Hu Y. , Wu J. , Dai C. , Wang H. , Tu Y. , Peng X. , Wang Y. , Zhai Q.
Hepatology59:2196-2206(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
72.

"Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression."
Annayev Y. , Adar S. , Chiou Y.Y. , Lieb J. , Sancar A. , Ye R.
J. Biol. Chem.289:5013-5024(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CIART
73.

"Modulation of glucocorticoid receptor induction properties by core circadian clock proteins."
Han D.H. , Lee Y.J. , Kim K. , Kim C.J. , Cho S.
Mol. Cell. Endocrinol.383:170-180(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GR REPRESSION
74.

"A novel protein, CHRONO, functions as a core component of the mammalian circadian clock."
Goriki A. , Hatanaka F. , Myung J. , Kim J.K. , Yoritaka T. , Tanoue S. , Abe T. , Kiyonari H. , Fujimoto K. , Kato Y. , Todo T. , Matsubara A. , Forger D. , Takumi T.
PLoS Biol.12:E1001839-E1001839(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CIART
75.

"Molecular architecture of the mammalian circadian clock."
Partch C.L. , Green C.B. , Takahashi J.S.
Trends Cell Biol.24:90-99(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
76.

"Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex."
Huang N. , Chelliah Y. , Shan Y. , Taylor C.A. , Yoo S.H. , Partch C. , Green C.B. , Zhang H. , Takahashi J.S.
Science337:189-194(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 69-453 IN COMPLEX WITH CLOCK;FUNCTION;INTERACTION WITH CLOCK;MUTAGENESIS OF LEU-102; LEU-122 AND ILE-323

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